I wish everyone could have access to Dr. Eva's personal care and attention. The Fatigue Solution is the next best thing—it's one book that should be on every woman's bedside table. Eve, Singer and Actress

 

Chapter 9 – Labs and Testing Resources


Most doctors have labs they prefer to use in their practice. I have used many labs in my practice, and in the book I indicated some of the more progressive labs that I currently work with. Since these labs typically do not work directly with patients, you might review their web sites and mention them to your doctor. In addition, some of the labs have doctor referral tools on their web sites, or if you call they will be happy to let you know a local doctor that provides their specific testing.

 

Comprehensive Metabolic Panel



On page 255, I mention Comprehensive Metabolic Panel testing. Here is some more information on this test:

CMPThis test allows me to target your specific nutritional and metabolic needs with a convenient finger stick blood and urine test. This unique profile takes a functional approach to determine areas of imbalance and/or deficiency. Even slight deficiencies can impact your body's ability to create energy, burn fat, and build brain chemicals. The test provides information about oxidative stress and energy production by looking at potential insufficiencies of a group of nutrients including carnitine, NAC, lipoic acid, and CoQ10. It will determine your body's inflammatory potential based on fatty acid balance. The most effective and efficient combination of nutritional products will be selected for you based on your individual test results.

There are a variety of labs that provide the CMP test, and you can ask your doctor for more details. This is also a test that I sell on my web site. We send you the CMP test kit and you return the kit items in a shipper that is included. The lab will process the test and we provide you with the results, and a 15 minute telephone evaluation with our Nutritionist when the test results are received. You can click here to order this test


I listed some of the basic information on labs in the book, but for those readers who want more details on the labs and some of the diagnostic tests, I have listed them here. I also encourage the readers to visit the various web sites for each lab. Some web sites are more patient-friendly than others, but they all offer helpful information.

SpectraCell Laboratories
10401 Town Park Drive
Houston, Texas 77072
800.227.5227
713.621.3101
www.spectracell.com
spec1@spectracell.com (e-mail)

 

Spectracell has a very informative web site that includes a doctor referral tool on the home page. I use Spectracell for Telomere testing, Micronutrient Tests and a variety of other diagnostic tests.

Telomere Test:
The first commercially available telomere analysis in the United States. A window to your patient's cellular age.

What does Telomere Testing measure?
Telomeres are sections of genetic material at the end of each chromosome whose primary function is to prevent chromosomal "fraying" when a cell replicates. As a cell ages, its telomeres become shorter. Eventually, the telomeres become too short to allow cell replication, the cell stops dividing and will ultimately die - a normal biological process. SpectraCell's Telomere Test can determine the length of a patient's telomeres in relation to the patient's age..

Telomere Testing

How are the results reported?
The Patient Telomere Score is calculated based on the patient's telomere length on white blood cells (T-lymphocytes). This is the average compared to telomere length on lymphocytes from a sample of the American population in the same age range. The higher the telomere score, the "younger" the cells. A Telomere Score that is above the average line is desirable.

Telomore Testing

What do the results mean to the patient and the doctor?
Age adjusted telomere length is the best method to date to assess biological age using structural analysis of chromosomal change in the telomere. Serial evaluation of telomere length is an indicator of how rapidly one ages relative to a normal population. Therapies directed at slowing the loss of telomere length may slow aging and age-related diseases.

Telomore Testing

What are the nutritional implications on telomere length and repair?
An inflammatory diet, or one that increases oxidative stress, will shorten telomeres faster. This includes refined carbohydrates, fast foods, processed foods, sodas, artificial sweeteners, trans fats and saturated fats. A diet with a large amount and variety of antioxidants that improves oxidative defense and reduces oxidative stress will slow telomere shortening. Consumption of 10 servings of fresh and relatively uncooked fruits and vegetables, mixed fiber, monounsaturated fats, omega-3 fatty acids, cold water fish, and high quality vegetable proteins will help preserve telomere length. In addition, it is advised to reduce total daily caloric intake and implement an exercise program. Fasting for 12 hours each night at least 4 days per week is recommended.

What lifestyle modifications are likely to be helpful?
One should achieve ideal body weight and body composition with low body fat (less than 22 % for women and less than 16 % for men). Decreasing visceral fat is very important. Regular aerobic and resistance exercise for at least one hour per day, sleeping for at least 8 hours per night, stress reduction, discontinuation of all tobacco products are strongly recommended. Bioidentical hormone replacement therapy may decrease the rate of telomere loss.

When should retesting be considered?
Testing should be done once per year to evaluate the rate of aging and make adjustments in nutrition, nutritional supplements, weight management, exercise and other lifestyle modifications known to influence telomere length.

What role will nutritional supplements play in slowing telomere shortening?
Oxidative stress will shorten telomere length and cause aging in cellular tissue. Antioxidant supplements can potentially reduce oxidative stress very effectively, which will ultimately improve oxidative defenses, mitochondrial function, reduce inflammation and slow vascular aging. Targeted supplementation is key, as antioxidants work synergistically and must be balanced to work most effectively and avoid inducing a pro-oxidant effect. Increasing antioxidant capacity at the cellular level is critical to maintaining telomere length.

Recent evidence suggests that a high quality and balanced multivitamin will also help maintain telomere length. Specifically, studies have linked longer telomeres with levels of vitamin E, vitamin C, vitamin D, omega-3 fatty acids and the antioxidant resveratrol. In addition, homocysteine levels have been inversely associated with telomere length, suggesting that reducing homocysteine levels via folate and vitamin B supplementation may decrease the rate of telomere loss. Similarly, conditions such as cardiovascular disease, insulin resistance, diabetes, hypertension, atherosclerosis and even dementia affect telomere length. Correcting subclinical nutritional deficiencies that may contribute to such diseases is crucial for telomere maintenance.

What pharmacologic treatments are known to slow telomere aging?

• Angiotensin converting enzyme inhibitors (ACEI)
• Angiotensin receptor blockers (ARB)
• Renin Inhibitors
• Statins
• Possibly Calcium channel blockers
• Possibly Serum aldosterone receptor antagonists
• Possibly metformin
• Aspirin
• Bioidentical Hormone Replacement Therapy

Control all known coronary heart disease risk factors to optimal levels

• Reduce LDL cholesterol to about 70 mg %, decrease
• LDL particle number and increase LDL particle size.
• Reduce oxidized LDL.
• Increase HDL to over 40 mg % in men and over 50 mg % in women and increase HDL 2 subfraction. Reduce inflammatory HDL and increase protective HDL.
• Reduce fasting blood glucose to less than 90 mg % and 2 hour post prandial or 2 hour GTT to less than 110 mg %. Keep Hemoglobin A1C to about 5.0% and keep insulin levels low.
• Reduce blood pressure to about 120/ 80 mm Hg
• Reduce homocysteine to less than 8 um/L
• Reduce HS-CRP to less than 1.0
• Maintain ideal body weight and composition.
• Stop smoking.
• Treat insulin resistance and metabolic syndrome.

Overall recommendations to maintain telomere length
Some clinicians have recommended reducing all known coronary risk factors, inflammation, oxidative stress, ADMA levels and angiotensin II levels or its action. At the same time, therapy should increase nitric oxide levels and nitric oxide bioavailability, increase arginine, increase endothelial progenitor cells, improve mitochondrial function and increase oxidative defenses. In addition, one should optimize hormone levels, exercise, sleep, nutrition and nutritional supplements. Fasting and caloric restriction should be part of the regimen as well.

Components:
Telomeres are sections of genetic material at the end of each chromosome whose primary function is to prevent chromosomal "fraying" when a cell replicates. As a cell ages, its telomeres become shorter. Eventually, the telomeres become too short to allow cell replication, the cell stops dividing and will ultimately die - a normal biological process. SpectraCell's Telomere Test can determine the length of a patient's telomeres in relation to the patient's age.

SpectraCell's Telomere Test analyzes:

• Lysis of Cells
• DNA Extraction
• Amplification

Micronutrient Test
Nutritional Status & Health

Background
Overwhelming scientific evidence confirms that vitamin deficiencies are associated with disease processes and the overall condition of one's health. Vitamin, mineral and antioxidant deficiencies have been shown to suppress immune function and contribute to chronic degenerative processes such as arthritis, cancer, Alzheimer's, cardiovascular disease and diabetes. This body of research has been reaffirmed by the Journal of the American Medical Association (June 19, 2002-Vol 287, No 23). 

Micronutrient Testing from SpectraCell Laboratories

SpectraCell Laboratories, Inc. is a CLIA accredited clinical laboratory that specializes in micronutrient testing. This patented process resulted from 18 years of research at the University of Texas. The micronutrient tests measures how micronutrients are actually functioning within your patients' white blood cells. These tests allow nutritional assessment of your patients for a broad variety of clinical conditions including arthritis, cancer, cardiovascular risk, diabetes, various immunological disorders, metabolic disorders and micronutrient deficiencies. Also offered by SpectraCell is a specialized profile of homocysteine, lipids and proteins to assess cardiovascular risk. 

SpectraCell's Tests Are More Advanced Than other Laboratory Tests
Before the introduction of the our tests, many diagnosis and risk assessments were based on clinical observation and measurements of static levels of certain nutrients in serum. Static serum levels are not always representative indicators for assessing cell metabolism and utilization. 

SpectraCell's micronutrient testing offers a unique means to scientifically assess the intracellular requirements of micronutrients that play an important role in overall health and wellness of your patients. Our tests measure the biochemical function of vitamins, minerals, amino acids and antioxidants, providing a powerful clinical assessment tool for your practice.

Our panels are designed to provide you with the most comprehensive nutritional analysis available. As the only lab that can offer a truly functional intracellular testing, SpectraCell also provides you with targeted nutrient repletion recommendations for those vitamins and minerals found to be deficient. 

Micronutrient Testing

SpectraCell's Patented Technology
SpectraCell's patented, chemically-defined control media contains the minimal amount of each essential micronutrient that is needed to support optimal lymphocyte growth or mitogenic response. The functional intracellular status of micronutrients involved in cell metabolism is evaluated by manipulation of the individual micronutrients in the media followed by mitogenic stimulation and measurement of DNA synthesis.

The same technology also provides a total antioxidant function test (SPECTROX™) which assesses the ability of cells to resist damage caused by free radicals and other forms of oxidative stress. Due to the considerable number of cellular antioxidants with extensive interactions, redundancies, repair and recharging capabilities, measuring total function is the most accurate and clinically useful way to assess your patients' capacity to resist oxidative damage.

Since lymphocytes are produced in the bone marrow and stored in the peripheral locations for long periods of time (the average life span of a lymphocyte is approximately four to six months), SpectraCell's measurements provide a powerful portrait of each patients' long-term nutrient status. This is analogous to the use of a glycosylated hemoglobin test to evaluate blood glucose levels over a one to three month period. 

Interpreting Test Results
SpectraCell provides easy-to-read test reports for the clinician and the patient. We've incorporated numerical and graphic representations for each result, and we offer repletion suggestions based on each patient's deficiencies. We've included easy-to-understand supplement information that explains the role of each nutrient found deficient, deficiency symptoms, how to obtain that nutrient in food and toxicity and RDI standards for adults.

SpectraCell's Patented Technology

Clinical Applications
Identifying the right patient is simple. Our diagnostic profiles offer a window to the cell that can provide improved healthcare for all patients. However, the potential for clinical benefit is particularly evident in these patient groups:

Clinical Applications

DISEASE THERAPY AND MANAGEMENT: Diagnose and treat nutritional risk factors that contribute to the therapy/management of many degenerative disease conditions. 

FAMILY HISTORY: Provide prevention measures for patients with family history of common chronic disease conditions. 

HIGH RISK GROUPS: Certain high risk groups are more susceptible to vitamin, mineral and antioxidant deficiencies that can affect treatment outcomes and overall health. 

PROACTIVE RISK ASSESSMENT: Provide customized prevention by early detection of nutritional deficiencies for proactive patients. 

CHALLENGING CASES: Gain insight into generalized complaints with no apparent specific disease source and to provide treatment options based on biochemical individuality.

The Fatigue Solution

The Fatigue Solution

General Information
Test Results:
Easy-to-read, comprehensive test results are returned within two weeks.
Each report provides a scientific analysis of your patients' nutritional deficiencies.

Additional Resources:
Clinical Support: 800-227-5227.
Web: www.spectracell.com

Pathway Genomics
4045 Sorrento Valley Blvd.
San Diego CA, 92121
www.pathway.com
877-505-7374

 

I was introduced to Pathways' Fit Test last year and was very impressed with this particular test. Here is some more information to help you:

Understand how your genes influence your body's response to diet, nutrition and exercise.

Get Fit and Stay Healthy!

The Pathway Fit ® report provides personalized information and recommendations based on your genetics to assist you in achieving the following goals:

• Understand your metabolism and dietary traits
• Optimize the effects of physical activity and exercise
• Enhance the nutritional balance of your diet

Pathway Genomics

What You Will Learn
By analyzing your genetic code, along with answers to a lifestyle questionnaire, the Pathway Fit report gives you the power to understand your metabolism, eating behaviors, and your response to exercise, as well as the best ways to reach and maintain a healthy weight and lifestyle.

Ask Your Doctor Find out how to order

Get Fit and Stay Healthy

Diet
Personalize your diet with genetics. The way we eat, how our bodies process foods, and our overall health are impacted by our genetics. Scientific studies have shown that the consumption of particular nutrients may turn certain genes on or off. Diet results are calculated to help select the best diet for you.

Diet

Eating Behaviors
Eating behaviors can have as much effect on health as our diet. Some of our behaviors are influenced by our genetics. Through the Pathway Fit report, we describe certain genetic markers that are associated with eating behaviors, such as excessive snacking and difficulty feeling full. With this information, you and your physician can modify your lifestyle to achieve ultimate wellness.

Eating Behaviors

Food Reactions
Your genetics may impact how your body responds to some foods. We report on genetic markers associated with caffeine metabolism, bitter and sweet taste sensitivity, as well as lactose intolerance and alcohol flush.

Food Reactions

Nutritional Needs
Vitamins are an important part of your health. The Pathway Fit report includes genetic markers associated with your likelihood of having lower levels of certain vitamins, such as folate and vitamins A, B2, B6, B12, C, D and E.

Nutritional Needs

Exercise
Exercise has long been shown to provide many health benefits. Your genes can affect how you respond to exercise - your chances of losing weight, improving your cholesterol levels, and other health benefits. Pathway Fit also reports on how your genetics may influence your exercise performance.

Exercise

Your Body and Weight
Your weight can be influenced by many genes. The Pathway Fit report includes genetic markers associated with metabolism, the tendency to regain weight after losing weight, as well as predisposition for obesity.

Your body and weight

Metabolic Health Factors
Good metabolic health can prevent serious health conditions. Your report includes genetic markers that are used to calculate your likelihood for having decreased HDL (good) cholesterol levels, as well as elevated LDL (bad) cholesterol, blood sugar and triglyceride levels. All of these are indicators of adverse metabolic health, which are precursors to various health conditions, including coronary artery disease, stroke and type 2 diabetes.

Unlock Your Potential For A Healthy Lifestyle
Collaborating with world-class scientists, medical professionals, geneticists, and nutritional and performance experts, Pathway brings you this groundbreaking new service with your individuality in mind.

Unlock your potential for a healthy lifestyle

This Pathway service analyzes over 75 genetic markers that have been shown to impact metabolism, exercise and energy use within the human body.

Through the examination of these genes, which are expressed in various organs, such as the brain, stomach, gut, muscle, pancreas, and directly in fat tissue, we are able to gain an insight into how your body processes sugars, fats, nutrients and vitamins. What's more, the Pathway Fit report includes detailed analysis on how your body may respond to exercise, and your potential response to certain foods, all of which may lead to healthy choices and a better lifestyle.

Genova Diagnostics
63 Zillicoa Street
Asheville, NC 28801
www.gdx.net
800-522-4762

 

Genova produces a variety of tests and I use several of their hormone and allergy tests. Here is some more information:

Ask yourself these simple questions to see if hormone testing may be right for you:

• Has your interest in sex diminished?
• Have you tried to conceive for a year without success?
• Do you experience hot flashes, vaginal dryness, urinary incontinence, depression, mood swings, or changes in sleep patterns or appetite?
• Do you experience irritability, bloating, headaches, breast swelling or mood swings in the week prior to menstruation?
• Do you experience irregular menstrual cycles, spotting, or heavy bleeding?
• Do you tend to have painful periods?
• Do you have excess facial hair?
• Is intercourse painful to due to vaginal dryness?
• Do you have a family history of breast or ovarian cancer?
• Are you at risk of heart disease due to smoking, overweight or family history?

Hormone imbalances contribute to the following diseases:
• Osteoporosis
• Breast cancer
• Endometrial cancer
• Heart disease
• Endometriosis
• Polycystic ovary disease

Conditions caused or aggravated by imbalanced hormones:
• Low libido
• Infertility
• Miscarriage
• PMS
• Symptoms of menopause
• Menstrual irregularity

FEMALE HORMONES
Hormones are tremendously complex. During the premenopausal years, imbalanced hormones can pose challenges with mood stabilization, conception and regulation of your menstrual cycle.

Many women entering their 40s or 50s experience a range of symptoms from hormonal imbalance, including loss of sex drive, "brain fog", weight gain, hot flashes, irregular menstrual cycles, vaginal dryness, urinary incontinence, depression and/or changes in sleep patterns.
From the onset of your period through menopause and beyond, proper hormone balance affects many of the issues most important to you: sex, fertility, relationships and even your outlook on life. Establishing baseline measures is essential to determining the need for hormone replacement therapy (HRT) or other means of balancing hormones.

There are safe and effective ways to synchronize hormone levels. Patients are often surprised at how easy it is to remedy these problems and how great they feel once they have embarked on a plan with their health care provider. Ask your doctor about the benefits of hormone testing. One or more of these Genova tests may be right for you:

• Hormone Health
• Rhythm Plus
• Menopause Plus
• Complete Hormones
• Essential Estrogens
• Comprehensive Melatonin Profile
• Comprehensive Thyroid Assessment
• Adrenocortex Stress Profile
• Bone Resorption Assessment

OSTEOPOROSIS
Osteoporosis is a disease that results from bone loss, gradually leading to bone weakening. Reduced height, stooped posture, fractures, and deformities may result. Most diagnostic tests only confirm bone loss after it has occurred. Genova Diagnosticsʼ Bone Resorption Assessment detects early active bone loss before it becomes a problem, allowing you to take preventive
action.

MELATONIN PRODUCTION
Melatonin possesses powerful anti-aging and anti-cancer properties, and enhances sleep. Low levels may be associated with insomnia, menstrual irregularities and/or infertility. High levels may be associated with depression.

THYROID FUNCTION
The thyroid gland secretes hormones that regulate your metabolism. Disruptions can slow down or speed up your bodyʼs metabolism, resulting in fatigue, hair loss, dry skin, weight gain or loss, changes in menses, high blood pressure and/or heart problems.

ADRENAL FUNCTION
The adrenal glands produce several hormones, including DHEA and cortisol. When out of sync due to stress and other influences, these hormonal imbalances can cause weakness, and fatigue.

Sanesco International, Inc.
1010 Merrimon Ave.
Asheville, NC 28804
www.sanesco.net
Phone: 866.670.5705

 

Sanesco has a patient-friendly section of their web site that is full of great information. Here is a brief overview.

Your Health In Balance

Sanesco is a medical company that helps practitioners assess, monitor, and correct, the underlying causes of many chronic symptoms you may be experiencing, which may likely be associated to imbalances in your body's "Communication System." Utilizing Sanesco's revolutionary natural and non-drug clinical model, your practitioner can uncover imbalances in your body's Communication System and correct many of the symptoms that you experience.

If you have any of the following symptoms, you may have imbalances in your Communication System:

• Mood disorders: depression, anxiety, OCD (obsessive-compulsive disorder)
• Sleep disorders: insomnia, unable to stay asleep, sleep apnea
• Metabolic disorders: fatigue, low stamina, low body temperature, hypoglycemia, diabetes
• Memory disorders: poor recall, unable to focus
• Eating disorders: cravings, lack of appetite control
• GI disorders: IBS with constipation or diarrhea
• Hormonal disorders: PMS, peri-menstrual symptoms, low libido
• Pain disorders: joint pain, headaches, fibromyalgia

We invite you to join the growing number of people who have reclaimed their health and sense of wellbeing by rebalancing the body's Communication System. Talk to your clinician, or contact Sanesco today to find out how we can help your clinician help you.

Frequently Asked Questions

Frequently Asked Questions

What is the body's "Communication System"?

The brain initiates signals to the body in the form of chemical messages called neurotransmitters. These neurotransmitters further stimulate the body's glands, which secrete hormones. These hormones travel throughout the body and attach to the organs of the body at what are called "receptors."

If there is a breakdown in this system, the message is either incorrect, or the signal too strong or weak, resulting in symptoms throughout the body.

How do I know if I have imbalances in the Communication System?

An initial assessment is an important first step in reestablishing your health and wellbeing. Identifying the beginning of an imbalance allows correction before it has heavily impacted your health. A series of assessments, however, is an important part of a program designed to correct the cause(s) of symptoms and conditions such as those listed above. Your clinician will first run a baseline test that includes easy non-invasive urine collection and saliva collection. He/she will provide you with a collection kit to take home, collect your samples as instructed in the kit and use the self-addressed mailer to return it to the lab.

Your clinician will receive your report from the lab within a couple weeks. This  information will help your clinician identify imbalances in your communication system. He/she will then make treatment recommendations that include natural formulas specifically targeted to address the imbalances that were detected, plus any lifestyle changes that may be needed.

As part of a complete program, you will be retested and, if necessary, changes made to your initial protocols by your clinician. Once you reach a state of optimal balance, your clinician may suggest a protocol for you to maintain and prevent further symptoms that should preserve your state of health until you return for your usual checkup.

Do you have a glossary of CSM terminology to help me learn more?

Yes, our online Glossary defines the concepts, products, and terms that comprise the CSM model.

How do I tell my clinician about your services?

You can take the information from this web site to your present clinician. Or you can call Sanesco, and we will be happy to contact your clinician on your behalf. If you do not presently work with a healthcare provider who is familiar with our services, you may call our toll free number for a provider near you: 866-670-5705.

Metametrix Clinical Laboratory
3425 Corporate Way
Duluth, GA 30096
800-221-4640
www.metametrix.com


Metametrix has a very informative web site full of information. Rather than try to repeat it here, I suggest you go directly to their site. They have a section that is geared toward patients, as well as a doctor referral tool. Here is a more information on this particular lab:

Working to fulfill that mission

Much of the healthcare industry is focused on treating symptoms rather than investigating underlying causes of disease. At Metametrix, our mission is to improve health worldwide by providing clinical laboratory services in the area of nutrients, toxicants, hormonal balance, biotransformation and detoxification, gastrointestinal function, and the microbiome. Physicians use our services to custom tailor nutritional therapies, detoxification programs, and other lifestyle changes for the prevention, mitigation, and treatment of complex chronic disease.

FounderIn 1984, Metametrix founder J. Alexander Bralley began applying this new approach by offering testing for one important group of nutrients-amino acids. Wanting to expand these offerings to include other nutrients and add tests for toxicities that place increased stress on healthy function, he assembled a team of clinical laboratory specialists, researchers and clinicians. Today Metametrix offers an array of tests that reflect genetic, environmental and lifestyle influences on nutrient needs.

Metametrix is recognized internationally as a pioneer and leader in the development of nutritional, metabolic and toxicant testing. We have introduced several firsts in the industry, including:

• quantitative organic acid analysis to identify nutrient and other metabolic imbalances
• quantitative fatty acid analysis
• multi-profile combinations for "comprehensive" analysis of nutrients and toxicities
• fingerstick technology for a noninvasive option
• DNA identification of gut microbes

Next Generation Technology
We continue to develop innovative testing profiles with "Next Generation Technology" to further advance treatment options for chronic diseases such as cardiovascular, gastrointestinal, inflammatory, mental/emotional, and autism spectrum disorders. We currently have five patents pending for new methods and applications with more in the pipeline.

As an early adopter of advances in laboratory science, Metametrix functions as a reference provider for other clinical laboratories wanting to offer our innovative services to their clients. Metametrix also performs testing for research institutions as they study the influence of nutrients and toxicities on health.